I also tried something. I turned my wi-fi off, and you know what? The programs stopped working, and here I am on a short break at my work. I turned the wi-fi back on and the wineskin wrappers were working again. I don't know how, there's something about my work's wi-fi connection that's causing them to work correctly.
Could it be that you have apps that need a working net to run?
Sounds like a DRM- issue.